SEDATIVE
  Glaxon Sedative is the perfect end-of-day formula designed to help promote rest, relaxation, and recovery. Glaxon Sedative is a fine mix of inhibitory amino acids, growth hormone secretagogues, and anxiolytic components combined to elicit a blissful nose-dive right into bed. WHY WOULD I TAKE IT? Ever feel like your pre-workout is lasting a little too long from your evening workout?  Maybe if you had something to take the edge off, you could actually get to sleep on time.  This is where Sedative does the most work, by being designed to bring those energy levels back down so you can get the right amount of sleep you need to properly recover. HOW DOES THIS WORK? Sedative works mostly by providing the “inhibitory” (as opposed to excitatory) neurotransmitters Glycine, GABA, and somewhat Serotonin.  Some of these amino acids and extracts have a “secretagogue” effect in that they can elicit the release of growth hormone from the pituitary.  Additionally, Sedative provides other components like Theanine and Melatonin to reduce stress and promote sleep. HOW MUCH SHOULD I TAKE? Simply dissolve ½ to 1 full scoop of Sedative into 16oz (500mL) into water and mix vigorously.  Consume 90 minutes prior to desired effect or before bedtime. To assess tolerance, start with ½ scoop, and if well-tolerated, up to 1 scoop can be taken every 24 hours. Methods Behind the Madness: Sedative by Glaxon When trying to get a restful night’s sleep, what is it that you’re really missing that keeps you from dozing off?  Did you take your pre-workout too late in the day? Do the stressors of daily life have a million thoughts running through your head in anticipation of tomorrow?  Sedative is Glaxon’s “End of Day” formula that is designed to soothe, relax, and de-stress the body so it can recover the best way it knows how - sleeping. Amino acids as Neurotransmitter & Neurohormone ModulatorsInitially we sought out the main inhibitory amino acids that can act as neurotransmitters to help promote relaxation and a calm state of being.  This begins with two specific inhibitory amino acid neurotransmitters: L-Glycine and GABA (Gamma-Aminobutyric Acid). L-Glycine is actually the simplest of all amino acids, it’s sweet tasting and only has a single hydrogen atom in its side chain.  The main functions of Glycine occur in the retina, spinal cord, and brainstem where Glycine activates its receptor - causing a subsequent influx of chloride into neurons - and this causes what is known as “inhibitory postsynaptic potential” making neurons slow down and less likely to fire.  There have been several studies that have analyzed L-Glycine supplementation in humans and have shown statistically significant improvements in “feelings of fatigue”1, increases in Glycine concentrations in the Central Nervous System2, and decreasing daytime sleepiness with improvements in performance of memory recognition tasks3.  However, L-Glycine isn’t the main inhibitory neurotransmitter in the body - that role belongs to Gamma-Aminobutyric Acid or GABA.  GABA is the principal inhibitory (vs. excitatory) neurotransmitter and it is estimated that at least 20% of all brain neurons are “GABAergic”4.  Like the L-Glycine receptor, the GABAA receptor regulates the flux of Chloride (Cl-) ions across neuronal membranes.  Now, there are several different subtypes of GABA receptors - some of which control the flow of other ions such as Calcium or Potassium, which also regulate membrane potential.  Interestingly, GABA has varied attractions to each of its own receptors with the highest binding affinity actually for GABAC, which also has the longest binding duration and effect of any of the other GABA receptor subtypes5.  In most cases of GABA receptor activation, deeper slow-wave sleep is enhanced6.  Due to the high affinity of GABA to GABAC receptors, this leaves more possibilities for co-activations of other forms to be taken in conjunction with GABA supplementation.A potential GABA-synergy with another amino acid, L-Theanine was studied in 2019.  This combination of GABA and L-Theanine showed statistically significant effects over controls, but also over either amino acid administered individually.  There was significant increases in REM sleep, and non-REM sleep, sleep duration, and a significant decrease in sleep latency7.  L-Theanine appears to be another interesting amino acid.  Though it isn’t part of the traditional 20 proteogenic amino acids, L-Theanine is most commonly obtained in the diet through supplementation or ingestion of white tea.  L-Theanine is reported to cross the blood-brain barrier and influence the secretion and function of neurotransmitters in the CNS at approximately 30-minutes after oral administration8, and reaches peak concentration at 5-hours post-administration before its effects begin to diminish9.  Perhaps what is most interesting about L-Theanine is the range of receptors that it is capable of modulating, since there’s no endogenous receptor for L-Theanine itself.  Because of this, L-Theanine acts on AMPA, Kainate, and NMDA receptors of the brain10.  Since these receptor types are most commonly stimulated by glutamate (an excitatory amino acid neurotransmitter) they’re most prone to excitatory responses. L-Theanine actually has an antagonistic relationship with these receptors, this results in inhibition instead of excitation - and this decreases perceptual stress levels11.  Additionally, L-Theanine has been studied for its effects on anxiety in comparison to alprazolam (Xanax).  What was interesting about this study is that the comparative drug, alprazolam, had no anxiety dampening effects at rest or when faced with an anticipatory anxiety (inevitable electric shock) however, L-Theanine did have more significant relaxing effects under resting conditions12.Another key amino acid found in Sedative is L-DOPA from extracted Mucuna pruriens or Velvet Bean.  What’s interesting about this amino acid is that it does cross the blood brain barrier and is the most common precursor to the neurotransmitter, dopamine.  Coincidentally, Sedative also contains the amino acid precursor to serotonin in the form of 5-Hydroxytryptophan. However, once L-DOPA is converted into dopamine - this can also yield substantial amounts of adrenaline and norepinephrine as well.  L-DOPA happens to also have another peculiar mechanism that hasn’t been fully elucidated - the subsequent release of Growth Hormone-Releasing Hormone from the hypothalamus13.  Though many studies have tried uncovering this mechanism behind L-DOPA’s stimulative effect of growth hormone levels, perhaps the one that is most plausible is that L-DOPA provides precursors to dopamine, which in turn can become norepinephrine and stimulate alpha-adrenoreceptors - which could then stimulate a release of growth hormone14.   Botanicals that SedateNext in Sedative are an interesting pair of herbal extracts that help further magnify the effects of this “end of day” formula.  The common Magnolia tree (Magnolia officinalis) contains two compounds worthy of note: Magnolol & Honokiol.  These two compounds are actually isomers of one another, but are commonly referred to collectively.  Magnolol and honokiol can cross the blood-brain barrier15, can act as muscle relaxants16, and can diminish the release of histamine17 & leukotrienes18.  Needless to say that all of these features are desirable for a relaxation formula, but Mangolol and Honokiol form some other helpful synergies in Sedative.  First, it has an additive effect with L-Theanine being an antagonist of NMDA and metabotropic Glutamate receptors that have an inhibitory effect on the CNS19. Secondly, it has another potential additive effect when co-administered with GABA - where GABA predominates the GABAC receptors, while Magnolol & Honokiol occupy GABAA receptors20.The second herbal extract that is most prominent in Sedative comes from Corydalis yanhusuo which

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